In vitro anti-arthritic activity of cnidoscolus aconitifolius latex extract by protein denaturation method

Abstract

The study is intended to gauge the Latex of Cnidoscolus aconitifolius for commended anti-arthritic activity using in vitro approach. These were analyzed by inhibition of protein denaturation method. Acetyl salicylic acid was used as a standard drug. Results revealedthat the petroleum ether extract of Cnidoscolus aconitifolius latex at four different concentrations influenced significant anti-arthritic activity as compared to standard used drug. The latex petroleum ether extract showed better activity. In the study, petroleum ether extract of Cnidoscolus aconitifolius latex inhibited heat induced protein denaturation and may be one of the reasons of possessing anti-arthritic activity. It can be concluded that petroleum ether extract of Cnidoscolus aconitifolius latex possess good anti-arthritic activities. The medicinal value of Cnidoscolus aconitifolius latex and make reasons why this is used traditionally for various diseases. From this study we conclude that it is promising to develop a latex based anti-arthritic drug for the ailments of rheumatic diseases and other associated diseases.