Comparison of CRP with blood culture in the diagnosis of neonatal septicaemia

Abstract

Introduction: In neonates, septicaemia is one of leading cause of morbidity and mortality. Therefore, timely diagnosis is important to prevent fatal outcome. C-reactive protein is an important biomarker that aids in the timely diagnosis of neonatal septicaemia. Aim: The present study was carried out to compare the accuracy of CRP in the diagnosis of neonatal septicaemia with blood culture. Materials and Methods: 148 neonates diagnosed with neonatal sepsis were included in the study over a period of 6 months. Blood culture and semi-qualitative assessment of CRP was done for all the patients. Results: Of the 148 neonates studied, 53 were blood culture positive while 101 were CRP positive. The sensitivity, specificity, positive and negative predictive values and diagnostic accuracy of CRP were 86.7%, 43%, 45.5%, 85% and 69% respectively. Conclusion: The specificity and sensitivity of CRP against blood culture strengthen the use of this acute phase protein in the diagnosis of neonatal sepsis.