Surface plasmon resonance (SPR) biosensors are optical sensors exploiting special electromagnetic waves-surface plasmon-polaritons-to probe interactions between an analyte in solution and a biomolecular recognition element immobilized on the SPR sensor surface. Major application areas include detection of biological analytes and analysis of biomolecular interactions where SPR biosensors provide benefits of label-free real-time analytical technology. This paper reviews fundamentals of SPR affinity biosensors and discusses recent advances in development and applications of SPR biosensors. © Springer-Verlag 2003.
CITATION STYLE
Homola, J. (2003, October). Present and future of surface plasmon resonance biosensors. Analytical and Bioanalytical Chemistry. https://doi.org/10.1007/s00216-003-2101-0
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