Anti-α-Gal responses may exert a protective effect in falciparum malaria. However, the biological role of such antibodies is still unknown during Plasmodium vivax infections. We investigated IgG and IgM responses to α-Gal in individuals with vivax malaria. Anti-α-Gal IgG and IgM levels were higher in these patients than in controls, but no significant correlation was found between parasitaemia and anti-α-Gal response, nor between this response and ABO blood group status. This is the first study to investigate anti-α-Gal antibodies in P. vivax-infected patients; a larger survey is necessary to achieve a better understanding of host immune response during vivax malaria.
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Coelho, Z. B. de A., Mourão, L. C., Rodrigues, B. C. M., Cardoso-Oliveira, G. P., Hincapie, R., Sanhueza-Chavez, C., … Braga, É. M. (2019). Preliminary assessment of anti-α-gal IgG and IgM levels in patients with patent plasmodium vivax infection. Memorias Do Instituto Oswaldo Cruz, 114(6). https://doi.org/10.1590/0074-02760190145