The Genetic Analysis Workshop 16 rheumatoid arthritis data include a set of 868 cases and 1194 controls genotyped at 545,080 single-nucleotide polymorphisms (SNPs) from the Illumina 550 k chip. We focus on investigating chromosomes 6 and 18, which have 35,574 and 16,450 SNPs, respectively. Association studies, including single SNP and haplotype-based analyses, were applied to the data on those two chromosomes. Specifically, we conducted a generalized linear model with regularization (rGLM) approach for detecting disease-haplotype association using unphased SNP data. A total of 444 and 43 four-SNP tests were found to be significant at the Bonferroni corrected 5% significance level on chromosome 6 and 18, respectively.
CITATION STYLE
Guo, W., Liang, C., & Lin, S. (2009). Haplotype association analysis of North American Rheumatoid Arthritis Consortium data using a generalized linear model with regularization. BMC Proceedings, 3(S7). https://doi.org/10.1186/1753-6561-3-s7-s32
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