A convenient synthesis of chiral 1,2,4-oxadiazoles from N-protected (α-aminoacyl)benzotriazoles

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Abstract

1,2,4-Oxadiazoles (4a-k, 6a-c, 7a-d, and 11a-f) derived from chiral α-amino acids were synthesized in 70-94% yields via a fast and easy procedure under mild conditions. They were shown to be at least 97% enantiomerically pure by HPLC and NMR. © ARKAT.

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Katritzky, A. R., Shestopalov, A. A., & Suzuki, K. (2005). A convenient synthesis of chiral 1,2,4-oxadiazoles from N-protected (α-aminoacyl)benzotriazoles. Arkivoc, 2005(7), 36–55. https://doi.org/10.3998/ark.5550190.0006.705

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