Abstract
The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh−/− mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4−CD8− double-negative (DN) thymocytes and for efficient transition from the earliest CD44+CD25− DN population to the subsequent CD44+CD25+ DN population and from DN to CD4+CD8+ double-positive cells.
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CITATION STYLE
Shah, D. K., Hager-Theodorides, A. L., Outram, S. V., Ross, S. E., Varas, A., & Crompton, T. (2004). Reduced Thymocyte Development in Sonic Hedgehog Knockout Embryos. The Journal of Immunology, 172(4), 2296–2306. https://doi.org/10.4049/jimmunol.172.4.2296
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