Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

Abstract

Zivanovic et al. develop a robust method for chemoselective persulfide labeling using dimedone-based probes to show that persulfidation is an evolutionarily conserved post-translational modification used by the cells to protect proteins from overoxidation caused by different stressors. Higher persulfidation levels, caused by pharmacological or dietary interventions, lead to better resistance to oxidative stress and longer life.