EPID-09. INCIDENCE OF GLIOMA IN A MIXED URBAN-RURAL COMMUNITY OF NORTH AMERICA: A POPULATION-BASED STUDY

  • Ryan C
  • Kaur H
N/ACitations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

BACKGROUND: Limited information is known about incidence trends of glioma and its characteristics in well-defined populations, especially in a mixed urban-rural setting of North America. We assessed glioma incidence and characterized it in the Olmsted County, Minnesota, population. METHODS: This population-based study utilized the Mayo Clinic Tumor Registry and the Rochester Epidemiology Project (NIH-funded medical record linkage system for Olmsted County residents). We assessed incidence of pathologically confirmed glioma between January 1, 1995, and December 31, 2014. Age- and gender- adjusted incidence rates per 100,000 person-years were calculated using the 2010 US white population. We compared incidence trends of glioma during our study period with Olmsted County data from 1950-1990. World Health Organization grading was used. RESULTS: We identified 135 incident glioma cases (93% white) with 20 pediatric cases (< 20 years at diagnosis) (50% female) and 115 adult cases (≥20 years at diagnosis) (44% female). The overall incidence rate (all ages) during our study period, 5.5, was the same as that in 1950-1990, 5.5. Adult males, 7.87, had a higher rate than females, 5.23. Incidence of pediatric (age <20) glioma was 2.5 (95% CI: 1.4-3.6) and 1.5 for Grade I astrocytoma (60% of pediatric cases). Adult glioma was 6.5 (95% CI: 5.3-7.7) overall and 4.3 for glioblastoma. Incidence rates increased from 2.11 for age 20-29 years to 11.51 for age 60+ years, most noticeably increasing after age 50. Glioblastoma became the predominant tumor type after age 40 (77%), while occurring in only 12% of adults <40 years. Majority (68%) of tumors in ages 20-39 were grade II/III. CONCLUSIONS: Given its methodology, this study likely offers the most reliable data for (1) assessing incidence of glioma by grade, and (2) trending glioma incidence, which appears stable to studies from this population dating back to 1950.

Cite

CITATION STYLE

APA

Ryan, C., & Kaur, H. (2016). EPID-09. INCIDENCE OF GLIOMA IN A MIXED URBAN-RURAL COMMUNITY OF NORTH AMERICA: A POPULATION-BASED STUDY. Neuro-Oncology, 18(suppl_6), vi57–vi57. https://doi.org/10.1093/neuonc/now212.235

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free