Formulation and Evaluation of Pantoprazole Floating Tablets

Abstract

Floating herbal tablets prolong the gastric residence time of drugs, improve bioavailability, and facilitate local drug delivery to the stomach. In this study, floating tablets containing alcoholic extract of amla as main active ingredient were prepared for the treatment of helicobacter pylori infection and gastric ulcers. The tablets containing alcoholic extract of amla, aqueous extract of ginger and fenugreek, Psyllium husk, HPMC K100M, Sodium Bicarbonate, Talc and magnesium stearate were prepared by direct compression method. Tablets were further evaluated for physical parameters like diameter, thickness, hardness, uniformity of weight and buoyancy time. Formulation was optimized on basis of buoyancy time. All of these tablets were evaluated and was found within the range. The buoyancy time of all tablet formulations was less than 2min and remained in floating condition throughout the study, maximum till 8 hours. The optimized formulation was found to be f1 which was having buoyancy time of 0.25min. Formulation containing psyllium husk, sodium bicarbonate and HPMC K100M in combination can be promising for gastro retentive drug delivery systems.