Quantitation of first-and second-generation antipsychotics by LC-MS/MS

Abstract

Antipsychotic drugs are becoming a larger part of the prescription drug market. In combination with-traditional indications for prescribing these drugs, new effective therapies are proving worthwhile as well. Here, a successful method for detecting both first-and second-generation antipsychotics is presented using a solid phase extraction method and LC-MS/MS detection. This method is used for many sample matrices and can also be used for detecting antidepressants, which are often prescribed in conjunction with antipsychotics. © 2012 Springer Science+Business Media, LLC.