Facile formation of chiral calixarene analogs incorporating cystine peptide into the macrocyclic ring

Abstract

Chiral calixarene analogs incorporating cystine peptide into their macrocyclic ring were easily prepared by the cyclization reactions of bis(chloromethyl)phenol-formaldehyde oligomers with cystine peptides in moderate yields. Circular dichroism (CD) spectra indicated the existence of the transmission of the chirality from peptide unit to phenol-formaldehyde oligomer moiety. © 2002 Pharmaceutical Society of Japan.