High-Fructose Consumption and the Epigenetics of DNA Methylation

Abstract

Epidemiological studies have been demonstrated that fructose, which are used for beverages, are associated with the incidence of metabolic disorders. However, the pathological mechanism of fructose effect remains unclear. Recently, there are accumulating evidences that nutrition status may induce epigenetic modification, which lead to cause several diseases such as diabetes. Interestingly, it is becoming clear that the adverse effect of fructose is mediated by epigenetic modifications. Here, this chapter describes the epigenetic effect of high-fructose consumption. Keywords Fructose metabolism • High-fructose corn syrup • Developmental origins of health and Disease (DOHaD) • Pregnancy • Programming • Nonalcoholic fatty liver disease • Metabolic syndrome • DNA methylation • Carnitine palmitoyl-trasferase 1A • Peroxisome proliferator-activated receptor-α • Uncoupling proteins • Mitochondrial DNA