Interleukin-17 (IL-17)-induced MicroRNA 873 (miR-873) Contributes to the Pathogenesis of Experimental Autoimmune Encephalomyelitis by Targeting A20 Ubiquitin-editing Enzyme

Abstract

Background: The regulatory mechanism of abnormal miRNA expression in astrocytes upon IL-17 stimulation remains unclear. Results: miR-873 induced by IL-17 promotes inflammatory cytokine production and aggravates demyelination in experimental autoimmune encephalomyelitis (EAE) through the A20/NF-κB pathway. Conclusion: IL-17 regulates miRNA expression in astrocytes, which affects the pathogenesis of EAE. Significance: These data provide a novel regulatory mechanism in inflammatory autoimmunity diseases.