Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis

31Citations
Citations of this article
90Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell phospholipid composition, and total ER lipid content, upon stimulation of cell growth can be explained by the cell cycle distribution of the population. TORC1 promotes phospholipid anabolism by slowing S/G2 progression. The cell cycle stage-specific nature of lipid biogenesis is dependent on p53. We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth.

Cite

CITATION STYLE

APA

Sanchez-Alvarez, M., Zhang, Q., Finger, F., Wakelam, M. J. O., & Bakal, C. (2015). Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis. Open Biology, 5(9). https://doi.org/10.1098/rsob.150093

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free