Structured sparse low-rank regression model for brain-wide and genome-wide associations

Abstract

With the advances of neuroimaging techniques and genome sequences understanding,the phenotype and genotype data have been utilized to study the brain diseases (known as imaging genetics). One of the most important topics in image genetics is to discover the genetic basis of phenotypic markers and their associations. In such studies,the linear regression models have been playing an important role by providing interpretable results. However,due to their modeling characteristics,it is limited to effectively utilize inherent information among the phenotypes and genotypes,which are helpful for better understanding their associations. In this work,we propose a structured sparse lowrank regression method to explicitly consider the correlations within the imaging phenotypes and the genotypes simultaneously for Brain- Wide and Genome-Wide Association (BW-GWA) study. Specifically,we impose the low-rank constraint as well as the structured sparse constraint on both phenotypes and phenotypes. By using the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset,we conducted experiments of predicting the phenotype data from genotype data and achieved performance improvement by 12.75% on average in terms of the rootmean- square error over the state-of-the-art methods.