In Vitro Antioxidant and Anti-Lipid Peroxidation Activities of Hydroalcoholic Extracts of Caralluma tuberculata, Root and Aerial Parts

1Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

Abstract

Background: Medicinal plants are considered as a useful source of antioxidants against diseases due to reducing free radicals. Caralluma tuberculata is one of such sources utilized by Iranian population as a traditional herbal medicine. Objectives: The present study aimed at investigating antioxidant activity, total phenolic content (TPC), and total flavonoid content (TFC) of C. tuberculata root hydroalcoholic extract (CRE) and aerial parts hydroalcoholic extract (CAE). Methods: Antioxidant properties were assessed using DPPH (1,1-dipheny l,2-picryl hydrazyl), superoxide anion (O2¯), nitric oxide (NO), ferric reducing antioxidant power, and anti-lipid peroxidation methods. TPC (mg pyrogallol/g extract) and TFC (mg quercetin/g extract) were measured by colorimetric methods. Results: The findings showed that both CAE and CRE were rich in phenolic and flavonoid compounds. TPC (40.12 ±1.2) and TFC (20.22 ± 0.62) were higher in CAE compared to CRE (TPC = 25.01 ± 0.85, TFC = 15.11 ± 0.71). Likewise, both CAE and CRE showed significant scavenging effects on DPPH, O2¯, and NO radicals and the effects of CAE was more potent (P < 0.05) compared to that of CRE. Also, plant extracts significantly inhibited lipid peroxidation in a dose-dependent manner (P < 0.05). Furthermore, CAE exhibited a more potent ferric reducing activity compared to CRE (510.21 ± 8.2 vs. 450.2 ± 9.3 µM Fe+2/g extract, respectively) (P < 0.05). Conclusions: Based on the study findings, both CAE and CRE could be considered as potential sources of antioxidants and CAE was more effective than CRE.

References Powered by Scopus

The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': The FRAP assay

18748Citations
N/AReaders
Get full text

Antioxidant determinations by the use of a stable free radical [10]

9680Citations
N/AReaders
Get full text

The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals

6989Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Cardioprotective potential of the antioxidant-rich bioactive fraction of Garcinia pedunculata Roxb. ex Buch.-Ham. against isoproterenol-induced myocardial infarction in Wistar rats

11Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Poodineh, J., & Nakhaee, A. (2019). In Vitro Antioxidant and Anti-Lipid Peroxidation Activities of Hydroalcoholic Extracts of Caralluma tuberculata, Root and Aerial Parts. Jundishapur Journal of Natural Pharmaceutical Products, 14(4). https://doi.org/10.5812/jjnpp.69685

Readers' Seniority

Tooltip

Lecturer / Post doc 1

50%

PhD / Post grad / Masters / Doc 1

50%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 1

33%

Chemical Engineering 1

33%

Pharmacology, Toxicology and Pharmaceut... 1

33%

Save time finding and organizing research with Mendeley

Sign up for free