Inert gas washout from tissue may be analyzed using Krogh's cylinder or a simplified model thereof, represented by a series arrangement of compartments. In particular with limited axial diffusion in tissue, washout from this model is multi-exponential, the rate of washout accelerating with time. To explain the experimentally observed multicomponent washout, in which washout retards with time, heterogeneity of flow and/or diffusing capacity to volume is required, either in series or in parallel compartments. While there appears to be a structural basis for both types of heterogeneity, parallel and series, a distinction between both on the basis of washout curves alone is impossible.
CITATION STYLE
Scheid, P., Meyer, M., & Piiper, J. (1984). Elements for modeling inert gas washout from heterogeneous tissues. Advances in Experimental Medicine and Biology, 180, 65–72. https://doi.org/10.1007/978-1-4684-4895-5_5
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