Rare KMT2A-ELL and novel ZNF56-KMT2A fusion genes in pediatric T-cell acute lymphoblastic leukemia

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Abstract

Background/Aim: Previous reports have associated the KMT2A-ELL fusion gene, generated by t(11;19)(q23;p13.1), with acute myeloid leukemia (AML). We herein report a KMT2A-ELL and a novel ZNF56-KMT2A fusion genes in a pediatric T-lineage acute lymphoblastic leukemia (T-ALL). Materials and Methods: Genetic investigations were performed on bone marrow of a 13-year-old boy diagnosed with T-ALL. Results: A KMT2A-ELL and a novel ZNF56-KMT2A fusion genes were generated on der(11)t(11;19)(q23;p13.1) and der(19)t(11;19)(q23;p13.1), respectively. Exon 20 of KMT2A fused to exon 2 of ELL in KMT2A-ELL chimeric transcript whereas exon 1 of ZNF56 fused to exon 21 of KMT2A in ZNF56-KMT2A transcript. A literature search revealed four more T-ALL patients carrying a KMT2A-ELL fusion. All of them were males aged 11, 11, 17, and 20 years. Conclusion: KMT2AELL fusion is a rare recurrent genetic event in T-ALL with uncertain prognostic implications. The frequency and impact of ZNF56-KMT2A in T-ALL are unknown.

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Panagopoulos, I., Andersen, K., Eilert-Olsen, M., Rognlien, A. G., Munthe-Kaas, M. C., Micci, F., & Heim, S. (2021). Rare KMT2A-ELL and novel ZNF56-KMT2A fusion genes in pediatric T-cell acute lymphoblastic leukemia. Cancer Genomics and Proteomics, 18(2), 121–131. https://doi.org/10.21873/CGP.20247

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