Pharmacokinetics of nimesulide

Abstract

Nimesulide (4-nitro-2-phenoxymethanesulfonanilide) is a non-acidic, non-steroidal anti-inflammatory drug (NSAID) usually administered orally in the form of tablets and granules (sachets). The normal dosage is 100 mg twice daily. Rectal administration of suppositories is also employed, although to a minor extent. Normal dosage for rectal administration is 200 mg twice daily. In some countries, a suspension of nimesulide and a topical formulation (gel) are also commercially available. Pharmacokinetic studies have been performed with all these formulations.