Background: Nutritional support is an important link between the response to injury and recovery in critical illness. Objective: Our goal was to evaluate energy and substrate metabolism in septic and nonseptic critically ill patients in the resting state and during the administration of standardized total parenteral nutrition. Design: This was a prospective, clinical cohort study of 25 consecutively admitted critically ill patients either with (n = 14) or without (n = 11) sepsis who received total parenteral nutrition. Resting energy expenditure was measured on days 0, 2, and 7 by indirect calorimetry. Energy and substrate balances were calculated on days 2 and 7. Results: Resting energy expenditure was not significantly different between septic and nonseptic patients on day 0 (2.65 ± 0.49 and 2.36 ± 0.56 kJ · min-1 · m-2, respectively). Energy balances were positive for both groups on days 2 (0.68 ± 0.4 and 0.74 ± 0.6 kJ · min-1 · m-2, respectively; NS) and 7 (0.65 ± 0.3 and 0.78 ± 0.5 kJ · min-1 · m-2, respectively; NS). Substrate balances were not significantly different between groups on days 0, 2, and 7. Resting energy expenditure on day 0 was negatively correlated with the severity of illness in septic patients only (r = -0.58, P < 0.05). Conclusions: Metabolic changes were not significantly different between septic and nonseptic critically ill patients during the administration of standardized total parenteral nutrition. A disease-specific macronutrient composition of total parenteral nutrition formulas does not seem to be necessary in either septic or nonseptic critically ill patients.
CITATION STYLE
Zauner, C., Schuster, B. I., & Schneeweiss, B. (2001). Similar metabolic responses to standardized total parenteral nutrition of septic and nonseptic critically ill patients. American Journal of Clinical Nutrition, 74(2), 265–270. https://doi.org/10.1093/ajcn/74.2.265
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