Study on Protein (IgG) Adsorption in Terms of Surface Modification of Cyclic Olefin Copolymer (COC) for Protein Biochip

Abstract

This paper presents the study of protein, immunoglobulin G (IgG), adsorption on the COC surfaces. The absorption of IgG on plasma-modified surfaces having different contact angle was shown to be distinctive, which may be advantageous in protein patterning. The comparison of normalized intensities of the adsorbed protein from front side with those from rear side is described to check functionality of COC as protein chip substrate in optical detection.