Epigenome data release: A participant-centered approach to privacy protection

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Abstract

Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access.

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Dyke, S. O. M., Cheung, W. A., Joly, Y., Ammerpohl, O., Lutsik, P., Rothstein, M. A., … Pastinen, T. (2015). Epigenome data release: A participant-centered approach to privacy protection. Genome Biology, 16(1). https://doi.org/10.1186/s13059-015-0723-0

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