Prognostic factors in colorectal cancer

Abstract

Aim: To evaluate prognostic factors in colorectal cancer. Material and methods: Published data (publications in PubMed, Scopus, eLIBRARY databases) and own results of treatment of 47 patients with T2-4N0-2M0 colon cancer in 2017–2018. The following prognostic factors were studied: Metastasis in regional lymph nodes, tumor site, CEA level, KRAS and BRAF mutation status, microsatellite instability, MUSASHI2, p53, VEGF.Results: A correlation between tumor progression and the status of regional lymph nodes demonstrated significant differences (p = 0.038): In N0, the risk of progression was 3.8%, in N1 — 14.9%, in N2 — 43.6%. Statistical processing of the results did not reveal significant differences between groups of patients without and with cancer generalization by their age, gender, tumor site, type of lymph node dissection, T stage, differentiation of adenocarcinoma, levels of CEA, mutations of KRAS, MSI, p53, MUSASHI2, VEGF. We used these prognostic factors to determine biological features of the tumor, its aggressiveness and treatment approaches. Conclusions: The status of regional lymph nodes remains the main factor in determining the prognosis of a colon tumor and in the medical therapy appointment. Molecular genetic factors are currently of great importance for determining tactics in personalized medical treatment.