Acute pulmonary thromboembolism caused by factor v Leiden mutation in South Korea: A case report

Abstract

Rationale:Although Factor V Leiden (FVL) mutation is a major cause of inherited thrombophilia in Western populations; the mutation is extremely rare in Asia.Patient concerns:Here we report a case of a 28-year old Korean woman admitted to our hospital with extensive pulmonary embolism.Diagnosis:She was heterozygous for FVL mutation up on evaluation, and screening for asymptomatic family members also revealed heterozygous FVL mutation for her mother.Interventions:Enoxaparin 1mg/kg was initiated, followed by rivaroxaban 15mg every 12hours.Outcomes:The patient showed improvement in both subjective dyspnea and right ventricular dysfunction and was successfully discharged after five hospital days.Lessons:FVL mutation screening may be considered in Asian patients with thrombophilia of uncertain etiology in the future.