Incidence of acute graft-versus-host disease with and without methotrexate prophylaxis in allogeneic bone marrow transplant patients

Abstract

Methotrexate has been used as the mainstay therapy to prevent or ameliorate graft-versus-host disease (GVHD) in allogeneic bone marrow transplantation. We began a nonrandomized study in which methotrexate was not given routinely. Fifty-five patients underwent transplant for acute leukemia (44 patients), asplastic anemia (6 patients), and other malignancies (5 patients). Methotrexate was given to 34 patients (MTX+) and was withheld in 21 patients (MTX-). Median (range) age of patients was 12 (0.8-43) years in the MTX+ group, and 16 (3-45) years in the MTX- group. Mean days (±SEM) to engraftment (neutrophils >500/μL, and platelets >20,000/μL untransfused) occurred earlier in the MTX- patients (19.6 2+ 1.4 v 24.9 ± 1.8 days for granulocytes, and 19.3 ± 1.5 27.4 ± 2.8 days for platelets, P