Sex-Specific Regulatory Systems for Dopamine Production in the Honey Bee

Abstract

Dopamine has multiple functions in the modulation of social behavior and promotion of reproduction in eusocial Hymenoptera. In the honey bee, there are sex-specific differences in the regulation of dopamine production in the brain. These different dopaminergic systems might contribute to the maintenance of sex-specific behaviors and physiology. However, it is still not fully understood how the dopaminergic system in the brain is regulated by endocrinal factors and social stimuli in the colony. In this review, we focus on the regulation of dopamine production in queens, workers, and males in the honey bee. Dopamine production can be controlled by queen substance, juvenile hormone, and exogenous tyrosine from food. Queens can control dopamine production in workers via queen substance, whereas workers can manipulate the supply of tyrosine, a precursor of dopamine, to queens and males. The regulation of dopamine production through social interaction might affect the reproductive states of colony members and maintain sex-specific behaviors in unpredictable environments.