Synthesis, characterization and preliminary study of the anti-inflammatory activity of new pyrazoline containing ibuprofen derivatives

Abstract

New ibuprofen derivatives containing variously substituted pyrazoline have been synthesized, characterized by FT-IR and 1H-NMR spectroscopy and evaluated preliminarily for their anti-inflammatory activity. In vivo anti-inflammatory activity of the final products (5a-f) was studied in rats using egg-white induced edema method of inflammation. All of them showed anti-inflammatory activity compared to the control group (propylene glycol) except compound 5f that showed more anti-inflammatory activity than ibuprofen.