Organizational structure of the transcriptional regulatory network of yeast: Periodic genes

Abstract

In this paper we investigate the organizational structure of the transcriptional regulatory network of S. cerevisiae with respect to the connectivity structure of periodic genes. We demonstrate that the giant strongly connected component plays a prominent role serving as central connector for genes experimentally found to be periodically expressed during the cell cycle of yeast. Numerically, we find by randomization of the gene labels that this organizational structure is unlikely to be formed by chance. © 2009 ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering.