In a new mouse model for generalized pain syndrome, including fibromyalgia, which used intermittent cold stress (ICS), bilateral allodynia in the hindpaw was observed that lasted more than 12 days; thermal hyperalgesia lasted 15 days. During constant cold stress (CCS), mice showed only a transient allodynia. A female prevalence in ICS-induced allodynia was observed in gonadectomized but not in gonad intact mice. Systemic gabapentin showed complete anti-allodynic effects in the ICS model at the one-tenth dose for injury-induced neuropathic pain model, and central gabapentin showed long-lasting analgesia for 4 days in ICS, but not the injury model. These results suggest that the ICS model is useful for the study of generalized pain syndrome. © 2008 Nishiyori and Ueda; licensee BioMed Central Ltd.
CITATION STYLE
Nishiyori, M., & Ueda, H. (2008). Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia. Molecular Pain, 4. https://doi.org/10.1186/1744-8069-4-52
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