Neurodegeneration and multiple sclerosis

Abstract

Neurodegeneration causes inexorable loss of neurons and function in both diseases and aging. Neurodegeneration damage produces a range of progressive disabilities from cognitive decline, behavioral and mood disorders to problems with movement, co-ordination, and sensory dysfunction. Neurodegeneration is a major and growing public health issue which in its broadest sense embraces classical neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease, as well as multiple sclerosis (MS), diabetes, and acute brain injury among many other conditions. This chapter discusses the clinical and pathophysiological features of neurodegeneration in MS.