Neoandrographolide

Abstract

Neoandrographolide is a colorless column crystal that has been isolated from the stem and leaves of Andrographis paniculata. Neoandrographolide and andrographolide are the main active ingredients of a variety of pharmaceutical preparations containing the Andrographis herb. These drugs are mainly used for treating acute bacterial dysentery, acute gastroenteritis, upper respiratory tract infection, acute tonsillitis, pharyngitis, etc. Neoandrographolide can inhibit lipopolysaccharide-induced NO production in the mouse peritoneal macrophages and inhibits the release of endothelin and malondialdehyde induced by oxidized low-density lipoprotein (ox-LDL) in the porcine aortic endothelial cells. It also shows a protective effect in endotoxemia mice, and the mechanism may be through downregulation of TLR4 and NF-kB mRNA expression. Neoandrographolide may be developed as an effective antibiotic drug with less side effects in the future.