The effect of combination ethanol extracts of bitter melon leaves, white turmeric rhizome and bangle rhizome on the sgot-sgpt levels and the liver histopathology profile of rats

Abstract

The leaves of bitter melon (Momordica charantia L), as well as rhizomes of White Turmeric (Curcuma zedoaria Rosc.) and Bangle (Zingiber cassumunar Roxb.), are some of the most commonly used plants in Indonesian herbal medicines. It was found that a combination of the three extracts was able to exhibit antimicrobial activity against Mycobacterium tuberculosis in vitro. We aim to observe the toxicity subchronically effect of the ethanol extracts of the plants, particularly in terms of the liver histopathological examination of rat models (Rattus norvegicus). The mixture extract was made into a suspension with various concentrations given for 28 days for 20 rats which were divided evenly into 4 groups. In this present study, The measurement results of SGOT (Serum Glutamic Oxaloacetic Transferase) and SGPT (Serum Glutamic Pyruvic Transferase) levels from rat blood were taken post-treatment period analyzed using One Way ANOVA showed that SGPT and SGOT did not increase significantly compared to the control group. Histopathological results showed group 1 had a mild le vel of hepatocyte cell damage compared to groups 2 and 3 which had moderate to severe damage.