GLYCATED HEMOGLOBIN (HBA1C) IS A PREDICTOR OF DYSLIPIDEMIA IN TYPE 2 DIABETES NEPALESE PATIENTS.

Abstract

Background: Type 2 diabetes mellitus (T2DM) have an increased prevalence of dyslipidemia. Dyslipidemia is characterized by high cholesterol (TC), high triglyceride (TG), high LDL cholesterol (LDL-C) and decrease HDL cholesterol (HDL-C) and is major risk factor for cardiovascular disease in T2DM. HbA1c serve as a gold standard indicator of glycaemic status over long term. Aim: The study aimed to investigate the correlations between lipid profile parameters, as well as the glycated hemoglobin (HbA1c) values of Nepalese population with type 2 Diabetes mellitus (T2DM). Material and Methods: This was a cross sectional, retrospective study of 140 T2DM patients (81 male and 59 female) who had visited department of Internal Medicine, Manmohan Memorial Community Hospital were included in this study. Venous blood samples were collected for fasting plasma glucose, HbA1c and serum lipid profile from all subjects in the morning after at least 8 hours fasting by using methods following standard operating procedures (SOPs). The statistical analysis was done by SPSS. Results: There is alteration in the serum levels of FBS, total cholesterol (TC), triglycerides, LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C) were noted in patients with T2DM. The HbA1c was found to be significant correlation with FBS, TC, TG, and LDL-C but there was no significant relation noticed with HDL-C. Values of HbA1c >6.5 % showed significant correlation with TC, LDL-C, TG, LDL-C/HDL-C and TC/HDL-C ratio, as compared to patients with HbA1c ≤ 6.5% (p<0.05). Conclusion: In conclusion, our study demonstrates that in Nepalese with type 2 diabetes mellitus, dyslipidemia is more common. To reduce the burden of morbidity and mortality from different complications, it necessary to control diabetes and lipid levels in diabetic patients and