Contraceptive use in women enrolled into preventive HIV vaccine trials: Experience from a phase I/II trial in East Africa

22Citations
Citations of this article
89Readers
Mendeley users who have this article in their library.

Abstract

Background: HIV vaccine trials generally require that pregnant women are excluded from participation, and contraceptive methods must be used to prevent pregnancy during the trial. However, access to quality services and misconceptions associated with contraceptive methods may impact on their effective use in developing countries. We describe the pattern of contraceptive use in a multi-site phase I/IIa HIV Vaccine trial in East Africa (Uganda, Kenya and Tanzania) and factors that may have influenced their use during the trial. Methods: Pregnancy prevention counseling was provided to female participants during informed consent process and at each study visit. Participants' methods of contraception used were documented. Methods of contraceptives were provided on site. Pregnancy testing was done at designated visits during the trial. Obstacles to contraceptive use were identified and addressed at each visit. Results: Overall, 103 (31.8%) of a total of 324 enrolled volunteers were females. Female participants were generally young with a mean age of 29(±7.2), married (49.5%) and had less than high school education (62.1%). Hormonal contraceptives were the most common method of contraception (58.3%) followed by condom use (22.3%). The distribution of methods of contraception among the three sites was similar except for more condom use and less abstinence in Uganda. The majority of women (85.4%) reported to contraceptive use prior to screening. The reasons for not using contraception included access to quality services, insufficient knowledge of certain methods, and misconceptions. Conclusion: Although hormonal contraceptives were frequently used by females participating in the vaccine trial, misconceptions and their incorrect use might have led to inconsistent use resulting in undesired pregnancies. The study underscores the need for an integrated approach to pregnancy prevention counseling during HIV vaccine trials.

Figures

  • Table 1. Demographic Characteristics of Female Study Participants by Site
  • Table 2. Duration of Contraceptive use prior to Screening, Contraceptive Methods Used at enrollment and Pregnancies Reported
  • Table 3. Pattern of Contraceptive Use at Enrolment by Selected Demographic Factors (All Sites)
  • Table 4. Use of Hormonal Contraceptives by Participant Characteristics*
  • Table 5. Previous Condom Use as Contraception by Participant Characteristics*

References Powered by Scopus

Covert contraceptive use: Prevalence, motivations, and consequences

133Citations
N/AReaders
Get full text

Immunogenicity of a recombinant human immunodeficiency virus (HIV) - Canarypox vaccine in HIV-seronegative Ugandan volunteers: Results of the HIV network for prevention trials 007 vaccine study

62Citations
N/AReaders
Get full text

Changes in contraceptive method mix in developing countries

52Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The effects of injectable hormonal contraceptives on HIV seroconversion and on sexually transmitted infections

67Citations
N/AReaders
Get full text

Nonmechanical roles of dystrophin and associated proteins in exercise, neuromuscular junctions, and brains

35Citations
N/AReaders
Get full text

Altruism motivates participation in a therapeutic HIV vaccine trial (CTN 173)

33Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Kibuuka, H., Guwatudde, D., Kimutai, R., Maganga, L., Maboko, L., Watyema, C., … Robb, M. (2009). Contraceptive use in women enrolled into preventive HIV vaccine trials: Experience from a phase I/II trial in East Africa. PLoS ONE, 4(4). https://doi.org/10.1371/journal.pone.0005164

Readers over time

‘12‘13‘14‘15‘16‘17‘18‘19‘20‘21‘22‘23‘24‘2505101520

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 40

63%

Researcher 15

24%

Professor / Associate Prof. 5

8%

Lecturer / Post doc 3

5%

Readers' Discipline

Tooltip

Medicine and Dentistry 24

41%

Social Sciences 18

31%

Nursing and Health Professions 11

19%

Psychology 6

10%

Save time finding and organizing research with Mendeley

Sign up for free
0