We demonstrate an active microfluidic platform that integrates dielectrophoresis for the control of silver nanoparticles spacing, as they flow in a liquid channel. By careful control of the nanoparticles spacing, we can effectively increase the surface-enhanced Raman scattering (SERS) signal intensity based on augmenting the number of SERS-active hot-spots, while avoiding irreversible aggregation of the particles. The system is benchmarked using dipicolinate (2,6-pyridinedicarboxylic acid) (DPA), which is a biomarker of Bacillus anthracis. The validity of the results is discussed using several complementing characterization scenarios. © 2012 American Chemical Society.
CITATION STYLE
Chrimes, A. F., Khoshmanesh, K., Stoddart, P. R., Kayani, A. A., Mitchell, A., Daima, H., … Kalantar-Zadeh, K. (2012). Active control of silver nanoparticles spacing using dielectrophoresis for surface-enhanced Raman scattering. Analytical Chemistry, 84(9), 4029–4035. https://doi.org/10.1021/ac203381n
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