PHARMACOGNOSTICAL AND PHARMACEUTICAL EVALUATION OF VIDANGA VATI

Abstract

Today sedentary life style has given birth to number of diseases. Abnormal food habits, style of living, greed, anger have become a part of life. Changing of life style of modern human being has created several disharmonies in his biological system. Therapeutic benefits are not available to millions suffering from endocrine diseases in India. Hypothyroidism is a hypo metabolic clinical state resulting from inadequate production of thyroid hormones for prolonged periods or rarely, from resistance of the peripheral tissues to the effects of thyroid hormones. Its incidence is increasing day by day and its name became common on the tongue of society. It occurs about five times more often in females than in males. Embelia ribes promoted as a weight loss agent that supposedly enhances thyroid function. The anti-obesity effect of aqueous extract of Embelia ribes in rat fed a high fat died may be through down regulation of leptin, TNF-a, SRFBP1, PPArY2 gene expression. Till date no clinical trial and pharmaceutical analysis of Vidanga Vati has been carried out, hence in the present study Vidanga Vati was subjected to pharmacognostical and pharmaceutical analysis. Pharmacognostical evaluation showed presence of sclereids, stone cells, oil globules, peri sperm cells, tannin contain, prismatic crystal, starch grain aleurone grain, simple fibre and spoon shaped epidermal cells. Pharmaceutical evaluation showed loss on drying 7.93 % w/w, pH 4.5. HPTLC results showed 10 spots at 254nm and 4 spots at 366 nm.