National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensable tools for epidemiological research. CML registries with a more comprehensive reporting may also provide complementary data on treatment outcome to those obtained from clinical trials. Reports from several European CML registries consistently show a crude annual incidence of 0.7–1.3/100,000, median age at diagnosis of 56–60 years and a male/female ratio of 1.2–1.7. The incidence of CML has been stable over time. Worldwide, variations in the reported incidence of CML may be due to methodological issues, but a true difference between different geographical areas and/or ethnical subgroups cannot be excluded. The prevalence of CML is less well known but has been estimated to 15–20/100,000 inhabitants with a steady increase due to the profound improvement in survival of these patients. In recent population-based studies, CML patients have an overall survival that is comparable to that shown in large clinical trials, though relative survival in patients >70 years is still decreased. The impact of socioeconomic factors and health-care settings related to long-term outcome, a possible increased risk of secondary cancer development and identification of adverse off-target effects related to the continuous administration of tyrosine kinase inhibitors are among areas of ongoing epidemiological research in CML.
CITATION STYLE
Höglund, M., Sandin, F., Simonsson, B., & Stenke, L. (2021). Epidemiology of Chronic Myeloid Leukaemia. In Hematologic Malignancies (pp. 37–48). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-71913-5_3
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