Nifedipine maintenance tocolysis and perinatal outcome: an individual participant data meta-analysis

32Citations
Citations of this article
99Readers
Mendeley users who have this article in their library.

Abstract

Background: Preterm birth is the leading cause of neonatal mortality and morbidity in developed countries. Whether continued tocolysis after 48 hours of rescue tocolysis improves neonatal outcome is unproven. Objectives: To evaluate the effectiveness of maintenance tocolytic therapy with oral nifedipine on the reduction of adverse neonatal outcomes and the prolongation of pregnancy by performing an individual patient data meta-analysis (IPDMA). Search strategy: We searched PubMed, Embase, and Cochrane databases for randomised controlled trials of maintenance tocolysis therapy with nifedipine in preterm labour. Selection criteria: We selected trials including pregnant women between 24 and 366/7 weeks of gestation (gestational age, GA) with imminent preterm labour who had not delivered after 48 hours of initial tocolysis, and compared maintenance nifedipine tocolysis with placebo/no treatment. Data collection and analysis: The primary outcome was perinatal mortality. Secondary outcome measures were intraventricular haemorrhage (IVH), necrotising enterocolitis (NEC), infant respiratory distress syndrome (IRDS), prolongation of pregnancy, GA at delivery, birthweight, neonatal intensive care unit admission, and number of days on ventilation support. Pre-specified subgroup analyses were performed. Main results: Six randomised controlled trials were included in this IPDMA, encompassing data from 787 patients (n = 390 for nifedipine; n = 397 for placebo/no treatment). There was no difference between the groups for the incidence of perinatal death (risk ratio, RR 1.36; 95% confidence interval, 95% CI 0.35–5.33), intraventricular haemorrhage (IVH) ≥ grade II (RR 0.65; 95% CI 0.16–2.67), necrotising enterocolitis (NEC) (RR 1.15; 95% CI 0.50–2.65), infant respiratory distress syndrome (IRDS) (RR 0.98; 95% CI 0.51–1.85), and prolongation of pregnancy (hazard ratio, HR 0.74; 95% CI 0.55–1.01). Conclusion: Maintenance tocolysis is not associated with improved perinatal outcome and is therefore not recommended for routine practice. Tweetable abstract: Nifedipine maintenance tocolysis is not associated with improved perinatal outcome or pregnancy prolongation.

References Powered by Scopus

Measuring inconsistency in meta-analyses

48630Citations
N/AReaders
Get full text

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials

25685Citations
N/AReaders
Get full text

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration.

13984Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Safety and efficacy of tocolytics for the treatment of spontaneous preterm labour

34Citations
N/AReaders
Get full text

Prevention and Therapy of Preterm BirthGuideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/025, February 2019) - Part 2 with Recommendations on the Tertiary Prevention of Preterm Birth and the Management of Preterm Premature Rupture of Membranes

22Citations
N/AReaders
Get full text

Effect of maintenance tocolysis with nifedipine in established preterm labour on pregnancy prolongation and neonatal outcome

18Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

van Vliet, E. O. G., Dijkema, G. H., Schuit, E., Heida, K. Y., Roos, C., van der Post, J. A. M., … Oudijk, M. A. (2016, October 1). Nifedipine maintenance tocolysis and perinatal outcome: an individual participant data meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology. Blackwell Publishing Ltd. https://doi.org/10.1111/1471-0528.14249

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 25

53%

Researcher 12

26%

Professor / Associate Prof. 6

13%

Lecturer / Post doc 4

9%

Readers' Discipline

Tooltip

Medicine and Dentistry 46

75%

Nursing and Health Professions 7

11%

Psychology 5

8%

Social Sciences 3

5%

Save time finding and organizing research with Mendeley

Sign up for free