Dual behavior of iodine species in condensation of anilines and vinyl ethers affording 2-methylquinolines

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Abstract

A metal-free, mild and efficient method for the synthesis of 2-methylquinolines was successfully developed by condensation of anilines with vinyl ethers in the presence of catalytic amount of iodine. Modification of both pyridine and benzene moieties was easily achieved by changing only the vinyl ether and aniline. In this reaction, the iodine species was revealed to show dual behavior; molecular iodine serves as an oxidant, while its reduced form, hydrogen iodide, activates the vinyl ether. The redox reaction between these iodine species enables the use of a catalytic amount of iodine in this synthetic method.

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Le, S. T., Yasuoka, C., Asahara, H., & Nishiwaki, N. (2016). Dual behavior of iodine species in condensation of anilines and vinyl ethers affording 2-methylquinolines. Molecules, 21(7). https://doi.org/10.3390/molecules21070827

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