We aimed to investigate the expression of caveolin- 1, -2, -3, and platelet-derived growth factor (PDGF) β receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF β receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p<0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p<0.001), high nodal stage (p=0.011), high cancer stage (p=0.005), estrogen receptor negativity (p=0.003), and tumor recurrence (p=0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p<0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC. © International Society of Oncology and BioMarkers (ISOBM) 2011.
CITATION STYLE
Koo, J. S., Park, S., Kim, S. I., Lee, S., & Park, B. W. (2011). The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer. Tumor Biology, 32(4), 787–799. https://doi.org/10.1007/s13277-011-0181-6
Mendeley helps you to discover research relevant for your work.