Antiobesity activity of ethanolic extract of Cassia auriculata in high fat diet induced obese rats

Abstract

Objective: The present work was undertaken to evaluate the effect of Cassia auriculata leaves extract in high fat diet induced obesity in rats. Methods: Male Wistar rats weighing 150-200 g were divided into orlistat standard, Normal control, HFD control & test groups (6 animals per group). All treatments were given orally, started after 6 weeks feeding with HFD (except normal control group) and continued for six weeks along with HFD. Weight gain, feed intake, BMI, Waist Hip Ratio, obesity index, lipid profile, blood glucose and body fat depots content were the parameters evaluated. Results: The ethanolic extract of Cassia auriculata leaves at 200 and 400 mg/kg/orally (from the end of 6 th week up to 12 th weeks) showed reduction in weight gain, feed intake (GM) feed intake (k/Cal) BMI, WHRatio, obesity index and significant decrease in serum glucose, Triglyceride, Total cholesterol, LDL, VLDL and increase in HDL level, and also significantly decreased body fat depots and oxidative stress when compared to high fat diet control group. Conclusion: It can be concluded that ethanolic Cassia auriculata leaves extracts exhibit significant anti obesity activity against high fat diet induced obesity model. We are reporting the anti obesity activity of the leaves, first time.