Photochemical internalization (PCI) is a novel technology for release of endocytosed macromolecules into the cytosol. The technology is based on the use of photosensitizers located in endocytic vesicles. Upon activation by light such photosensitizers induce a release of macromolecules from their compartmentalization in endocytic vesicles. PCI has been shown to increase the biological activity of a large variety of macromolecules and other molecules that do not readily penetrate the plasma membrane, including type I ribosome-inactivating proteins, immunotoxins, plasmids, adenovirus, various oligonucleotides, dendrimer-based delivery of chemotherapeutica and unconjugated chemotherapeutica such as bleomycin and doxorubicin. This review will present the basis for the PCI concept and the most recent significant developments. © 2010 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Berg, K., Berstad, M., Prasmickaite, L., Weyergang, A., Selbo, P. K., Hedfors, I., & Høgset, A. (2010). Photochemical internalization: A new tool for gene and oligonucleotide delivery. Topics in Current Chemistry, 296, 251–281. https://doi.org/10.1007/128_2010_63
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