Craniofacial langerhans cell histiocytosis: A rare case report

Abstract

Langerhans cell histiocytosis (LCH) is a rare haematological disorder characterised by accumulation and abnormal proliferation of bone marrow-derived Langerhans cells and mature eosinophils. The clinical presentation of patients with LCH may be localised or systemic, depending on the site and the degree of involvement. LCH may involve any bone, but the most commonly involved bones are long bones, pelvis, ribs, skull, vertebrae, and facial bones. In head and neck region, frontal and parietal bones are commonly involved followed by the jaws, with a predilection for mandible. In this report, we present a case of LCH involving the craniofacial bones in a 10-year boy, who presented initially with multiple ulcerative lesions on gingiva.