ACP and Amulet: Trials and Registries Results

Abstract

Stroke or systemic embolism is a devastating consequence of atrial fibrillation {(AF)} due to thrombus formation in the left atrial appendage {(LAA).} {AF} causes thrombus formation in the {LAA} due to both the loss of atrial systole and the unique anatomic features of the {LAA.} Oral anticoagulation is a well established and effective therapy to reduce the risk of stroke in {AF} patients, albeit with a risk of bleeding. {LAA} closure is a possible alternative to oral anticoagulation in the prevention of stroke or systemic embolism in {AF.}