Detection of Staphylococcus aureus with reduced susceptibility to vancomycin in a South African teaching hospital

  • Oosthuizen D
  • Walsh T
  • Weldhagen G
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Abstract

Fifty-six methicillin-resistant Staphylococcus aureus clinical isolates were collected over a two-month period from a large teaching hospital in Pretoria, South Africa. Isolates were subjected to screening and confirmatory testing for vancomycin hetero-resistance. Thirty-three isolates were identified with the macro-method Etest as possibly being hetero-resistant to vancomycin. Twenty randomly selected hetero-resistant isolates were subjected to population analysis profile, area under the curve ratio methodology, of which 18 were confirmed to be vancomycin hetero-resistant. As a screening test, the macro-method Etest thus exhibited high sensitivity and specificity, for detecting hetero-resistant S. aureus at this institution.

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Oosthuizen, D., Walsh, T. R., & Weldhagen, G. F. (2005). Detection of Staphylococcus aureus with reduced susceptibility to vancomycin in a South African teaching hospital. Southern African Journal of Epidemiology and Infection, 20(4), 127–129. https://doi.org/10.1080/10158782.2005.11441249

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