Objective sleep disturbances are associated with greater waking resting-state connectivity between the retrosplenial cortex/ hippocampus and various nodes of the default mode network

73Citations
Citations of this article
119Readers
Mendeley users who have this article in their library.

Abstract

Background: Psychological models highlight the bidirectional role of self-referential processing, introspection, worry and rumination in the development and maintenance of insomnia; however, little is known about the underlying neural substrates. Default mode network (DMN) functional connectivity has been previously linked to these cognitive processes. Methods: We used fMRI to investigate waking DMN functional connectivity in a well-characterized sample of patients with primary insomnia (PI) and good sleeper controls. Results: We included 20 patients with PI (8 men and 12 women, mean age 42.7 ± 13.4 yr) and 20 controls (8 men and 12 women, mean age 44.1 ± 10.6 yr) in our study. While no between-group differences in waking DMN connectivity were observed, exploratory analyses across all participants suggested that greater waking connectivity between the retrosplenial cortex/hippocampus and various nodes of the DMN was associated with lower sleep efficiency, lower amounts of rapid eye movement sleep and greater sleep-onset latency. Limitations: Owing to the cross-sectional nature of the study, conclusions about causality cannot be drawn. Conclusion: As sleep disturbances represent a transdiagnostic symptom that is characteristic of nearly all psychiatric disorders, our results may hold particular relevance to previous findings of increased DMN connectivity levels in patients with psychiatric disorder.

Figures

References Powered by Scopus

The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research

24670Citations
N/AReaders
Get full text

A new method for measuring daytime sleepiness: The Epworth sleepiness scale

13474Citations
N/AReaders
Get full text

A default mode of brain function

9991Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Functional reorganization in obstructive sleep apnoea and insomnia: A systematic review of the resting-state fMRI

126Citations
N/AReaders
Get full text

The insomnia with short sleep duration phenotype: An update on it's importance for health and prevention

82Citations
N/AReaders
Get full text

Insomnia Disorder and Brain’s Default-Mode Network

68Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Regen, W., Kyle, S. D., Nissen, C., Feige, B., Baglioni, C., Hennig, J., … Spiegelhalder, K. (2016). Objective sleep disturbances are associated with greater waking resting-state connectivity between the retrosplenial cortex/ hippocampus and various nodes of the default mode network. Journal of Psychiatry and Neuroscience, 41(5), 295–303. https://doi.org/10.1503/jpn.140290

Readers over time

‘16‘17‘18‘19‘20‘21‘22‘23‘24‘2507142128

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 37

65%

Researcher 11

19%

Professor / Associate Prof. 6

11%

Lecturer / Post doc 3

5%

Readers' Discipline

Tooltip

Psychology 22

42%

Neuroscience 19

37%

Medicine and Dentistry 7

13%

Agricultural and Biological Sciences 4

8%

Save time finding and organizing research with Mendeley

Sign up for free
0