Cardiac MRI characteristics in patients with borderline pulmonary hypertension: results from the ASPIRE registry

Abstract

Background: Pulmonary hypertension (PH) is a severe disorder defined as a mean pulmonary artery pressure (mPAP) >= 25mmHg at right heart catheterization. Previous research indicates the mPAP of healthy volunteers is 14mmHg (+/-3.3mmHg) at rest, and patients with mPAP of 21 to 24 mmHg are considered as borderline PH. This study investigates demographic, co-morbidities, invasive haemodynamics and cardiac magnetic resonance (CMR) imaging characteristics of patients with borderline PH. Method(s): Consecutive patients who underwent CMR at 1.5T at a large volume pulmonary hypertension centre were identified. CMR imaging was performed on a whole body scanner GE HDx at 1.5T (GE Healthcare, Milwaukee, USA) with an 8 channel cardiac coil. Exclusion criteria were non-diagnostic imaging or right heart catheterisation (RHC) >24 hours from time of CMR. Biventricular volume, mass and function, pulmonary artery form and function, left atrial (LA) volume and inter-ventricular septal (IVS) angle were assessed. All demographic, invasive haemodynamic and CMR and haemodynamic variables were compared between patients with normal pulmonary artery pressure (mPAP Result(s): 797 consecutive patients with suspected PH referred for CMR between April 2012 and March 2014 were identified. 83 patients had mPAP of less than 25, and 72 were included in this study having CMR within 24 hours of RHC. There was no significant difference between the age, sex distribution, body surface area, heart rate or cardiac output of the two groups. MRAP, PCWP and as expected PVR were significantly elevated in the borderline PH group. RVEDVI (p=0.025), IVS angle in systole (p=0.024) and LA volume (p=0.047) are all significantly higher in patients with borderline PH than those with mPAP<20mmHg. RV functional measurements were not elevated in patients with borderline PH. At bilogistic regression borderline PH was independently associated with elevated IVS angle. MPAP correlated significantly with RVEDVI (p=0.040) and IVS angle (p=0.046), and PVR correlated strongly with PA relative area change (p=0.001). Conclusion(s): Patients with borderline PH have higher indexed RV enddiastolic volume and greater septal deviation but preserved RV functional metrics when compared to patients with normal pulmonary artery pressure. Elevated PCWP and LA volume likely relates to the higher proportion of patients with underlying left heart disease in the borderline PH group. This is the first study to demonstrate changes in CMR cardiac morphology in patients with borderline pulmonary hypertension, these findings challenge the current definition of PH. (Figure Presented).