Therapeutic efficacy of vitamin a in the treatment of idiopathic microscopic hematuria in children

Abstract

Background: Hematuria is a symptom with a prevalence of 0.5% to 2% in those aged 5-12 years. Different factors can influence the severity of hematuria, including vitamin A (as a micronutrient). Objectives: The current study aimed to evaluate the therapeutic effect of vitamin A on hematuria in children. Methods: In this clinical trial study, 156 children aged 5-12 years with Idiopathic Microscopic Hematuria are studied. Participants were divided into two groups of treatment and control (each with 76 subjects). Those in the treatment group received vitamin A as a pearl of 25000 in 14 days, in addition to the routine treatment. The control group only received routine handling. The basic information of patients were recorded using an author-develop form by the supervisor and intern. Urine samples were collected on 14, 28, and 42 days. Data were analyzed using SPSS. Statistical significance was considered when P-value < 0.05. Results: There was no significant difference between the two groups concerning gender (P = 0.202), age (P = 0.330), father’s education (P = 0.152), mother’s education (P = 0.392), father’s occupation (P = 0.125), mother’s occupation (P = 0.265), and numbers of children in the family (P = 0.209) variables. Hematuria status on days 14 (P = 0.014), 28 (P = 0.001), and 42 after treatment (P = 0.001) was statistically more positive in the vitamin A group, compared to the placebo group. Hence, there was a significant difference between the two groups. Conclusions: Vitamin A can improve idiopathic microscopic hematuria. Hence, vitamin can be used as an alternative treatment to treat idiopathic hematuria in children.