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Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

  • Li J
  • Liu C
  • Schill A
  • et al.
Journal of Biomedical Photonics & Engineering (2015) 229-235
DOI: 10.18287/jbpe-2015-1-4-229
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Abstract

Purpose : Elastography is an emerging method for detecting the pathological changes in tissue biomechanical properties caused by various diseases. In this study, we have compared two methods of noncontact optical elastography for quantifying Young’s modulus of tissue-mimicking agar phantoms of various concentrations: a laser Michelson interferometric vibrometer and a phase-stabilized swept source optical coherence elastography system. Methods : The elasticity of the phantoms was estimated from the velocity of air-pulse induced elastic waves as measured by these two techniques. Results : The results show that both techniques were able to accurately assess the elasticity of the samples as compared to uniaxial mechanical compression testing. Conclusion : The laser Michelson interferometric vibrometer is significantly more cost-effective, but it cannot directly provide the elastic wave temporal profile, nor can it offer in-depth information.

Figures

  • Fig. 1 Schematic of PhS-SSOCE experimental setup.
  • Fig. 2 Schematic of LMIV experimental setup.
  • Fig. 3 Sample surface responses of a 1% agar phantom recorded during (a) OCE and (b) LMIV experiment at the indicated distances from the air-pulse excitation.
  • Fig. 5 Young’s modulus (E) estimated by the OCE system, LMIV, and as measured by mechanical testing (MT).
  • Fig. 4 Elastic wave propagation velocity measured by OCE and LMIV. Statistical testing was performed by a paired t-test to demonstrate that the velocity measurements made by both systems were not different. The respective P-values are labeled.
  • Table 1. Approximate cost in $US of the OCE and LMIV systems used in this study
  • Fig. 6 Phase velocity of the air-pulse induced elastic wave at 180 Hz in a sandwich-type agar phantom (top) with OCT image of the phantom (bottom). The layer boundaries are marked by the dashed red line.

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CITATION STYLE

APA

Li, J., Liu, C.-H., Schill, A., Singh, M., Nair, A., Zakharov, V., & Larin, K. (2015). Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry. Journal of Biomedical Photonics & Engineering, 229–235. https://doi.org/10.18287/jbpe-2015-1-4-229

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